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  • What is generalized myasthenia gravis (gMG)?

    gMG is an autoantibody-mediated disease driven by pathogenic B cells. It causes unpredictable fatigue and muscle weakness, that can affect the eyes, mouth and throat, neck, trunk, and limbs.1-3 Review gMG symptoms

  • What role do B cells play in gMG pathogenesis?

    B cells produce the autoantibodies that drive gMG disease activity. These include AChR, MuSK, and LRP4 autoantibodies.3,4 Read an overview of gMG

    AChR, acetylcholine receptor; LRP4, low-density lipoprotein receptor-related protein 4; MuSK, muscle-specific kinase.

  • How do autoantibodies affect the neuromuscular junction in gMG?

    Autoantibodies in gMG disrupt neuromuscular communication, resulting in impaired synaptic signaling and subsequent weakness and fatigability.4 Explore the mechanism of disease

  • References

    1. Masi G, O’Connor KC.  Curr Opin Neurol. 2022;35:586-596.

    2. Dresser L, Wlodarski R, Rezania K, Soliven B. J Clin Med. 2021;10:2235.

    3. Yi JS, Guptill JT, Stathopoulos P, Nowak RJ, O'Connor KC. Muscle Nerve. 2018;56(2):172-184.

    4. Huda R. Front Immunol. 2020;11:510568.